A two - year field experiment was conducted at the Teaching and Research Farm of the University of Ado - Ekiti, Nigeria, during 2004 and 2005 cropping seasons to evaluate the influence of tillage methods, position of minisetts on mother corm, and the interactions between these two treatments on the growth and yield parameters of cocoyam. The design was a split - plot configuration, laid out in a randomized complete block, with three replications. Minisett position on mother corm constituted the main-plot treatment, namely: head (top), middle and tail minisetts, while tillage methods i.e. conventional tillage (CT) and no – tillage (NT) were the sub-plot factors. The results obtained showed that there were significant differences ( P = 0.05) between tillage methods and position of minisetts on mother corm in growth and yield parameters of cocoyam. On the whole, the middle minisetts treatment gave 6.33 t ha-1 cocoyam cormels yield, which was not significantly higher than 6.30 t ha-1 recorded for the tail minisett. However, these two values were significantly higher than 4.79 t ha-1 for head minisetts. The CT gave 6.27 t ha-1 cocoyam cormel yield, which was significantly higher than 5.12 t ha-1 for the NT treatment. The interactions between tillage and minisett position significantly increased (P = 0.05) the growth and yield components of cocoyam. The treatment combination of middle minisett and CT resulted in the highest values of growth and yield of cocoyam in both years.