Two greenhouse trials were conducted at the Faculty of Agriculture, University of Benin, Benin City. The trials were organized in a completely randomized design with three replicates using five pond effluent concentrations namely: 0%, 25% (250ml fish effluent + 750ml distilled water), 50% (500ml fish pond effluent + 500ml distilled water), 75% (750ml fish pond effluent + 250ml distilled water) and 100% (1000ml fish pond effluent) to investigate the effect of fish pond effluent on the vegetative growth of maize (Zea mays L.) in an ultisol. Results showed that the soil organic carbon, nitrogen, exchangeable acidity and effective cation exchange capacity decreased significantly (P< 0.05) whereas the K, Ca, Mg and Na increased in the first cropping. The organic carbon, N, P, K, Mg, Ca and Na decreased further in the second cropping. The second cropping however did not show any trend of fish pond effluent on plant tissue. N, P, K, Mg, Ca and Na uptake by the maize increased with increasing fish pond effluent in the first cropping while in the second cropping, their uptake by the maize plant was not consistent with the increasing pond effluent. Plant height, stem girth and dry weight increased significantly (P< 0.05) with increasing fish pond effluent concentration, while in the second cropping, the leaf area and number of leaves were better than other parameters with increasing residual concentration of the effluents.